Chlamydia Infection in Murine Oviduct Epithelial Cells
نویسندگان
چکیده
Identifying a Role for TLR3 in the Innate Immune Response to 1 Chlamydia Infection in Murine Oviduct Epithelial Cells 2 3 Wilbert A. Derbigny†, LaTasha R. Shobe, Jasmine C. Kamran, Katherine S. Toomey, and 4 Susan Ofner 5 Department of Microbiology and Immunology, Department of Medicine, Department of 6 Biostatistics; Indiana University School of Medicine 7 Indianapolis, Indiana 46202 8 9 10 11 12 13 14 Running Title: TLR3-dependent inflammatory cytokine secretion elicited by C. muridarum 15 infection 16 17
منابع مشابه
The Chlamydia muridarum-induced IFN-β response is TLR3-dependent in murine oviduct epithelial cells.
Epithelial cells lining the murine genital tract act as sentinels for microbial infection, play a major role in the initiation of the early inflammatory response, and can secrete factors that modulate the adaptive immune response when infected with Chlamydia. C. muridarum-infected murine oviduct epithelial cells secrete the inflammatory cytokines IL-6 and GM-CSF in a TLR2-dependent manner. Furt...
متن کاملMurine oviduct epithelial cell cytokine responses to Chlamydia muridarum infection include interleukin-12-p70 secretion.
Epithelial cells play an important role in host defense as sentinels for invading microbial pathogens. Chlamydia trachomatis is an intracellular bacterial pathogen that replicates in reproductive tract epithelium. Epithelial cells lining the reproductive tract likely play a key role in triggering inflammation and adaptive immunity during Chlamydia infections. For this report a murine oviduct ep...
متن کاملPattern recognition molecules activated by Chlamydia muridarum infection of cloned murine oviduct epithelial cell lines.
Chlamydia trachomatis is the most common bacterial sexually transmitted disease in the United States and a major cause of female infertility due to infection-induced Fallopian tube scarring. Epithelial cells are likely central to host defense and pathophysiology as they are the principal cell type productively infected by C. trachomatis. We generated cloned murine oviduct epithelial cell lines ...
متن کاملIdentifying a role for Toll-like receptor 3 in the innate immune response to Chlamydia muridarum infection in murine oviduct epithelial cells.
Because epithelial cells are the major cell type productively infected with Chlamydia during genital tract infections, the overall goal of our research was to understand the contribution of infected epithelial cells to the host defense. We previously showed that Toll-like receptor 3 (TLR3) is the critical pattern recognition receptor in oviduct epithelial (OE) cells that is stimulated during Ch...
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